Fri Jul 15 2022

17 articles - From Friday Jul 08 2022 to Friday Jul 15 2022

parm_toc.knit

Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Kidney Dis

A Report of 2 Cases of Kidney Involvement in ADA2 Deficiency: Different Disease Phenotypes and the Tissue Response to Type I Interferon.

We stained Patient 2's kidney biopsy for the IFN I-induced protein MXA: this was markedly expressed within endothelial cells, especially in vessels with TMA, and in infiltrating T-cells. Our findings confirm that the kidney phenotype of ADA2 deficiency results from small and medium-sized vessel vasculopathy and suggest that IFN-I may be involved in the pathogenesis of kidney lesions.

Pubmed   Journal   ReadQx 

Association of Intra-individual Differences in Estimated GFR by Creatinine Versus Cystatin C With Incident Heart Failure.

Among persons with CKD who have large differences between eGFRcys and eGFRcr, risk for incident HF is more strongly associated with eGFRcys. Diverging slopes between eGFRcys and eGFRcr over time are also independently associated with risk of incident HF.

Pubmed   Journal   ReadQx 

Beyond the Urine Anion Gap: In Support of the Direct Measurement of Urinary Ammonium.

Ammonium is a major urinary buffer that is necessary for the normal excretion of the daily acid load. Its urinary rate of excretion (UNH holds promise to aid clinicians in the care of patients and we encourage further research to determine its best diagnostic usage.

Pubmed   Journal   ReadQx 

Self-reported Physical Activity and Cardiovascular Events in Adults With CKD: Findings From the CRIC (Chronic Renal Insufficiency Cohort) Study.

Higher self-reported physical activity was associated with lower risk of cardiovascular events and mortality in CKD patients, which may have important implications for clinical practice and the design of interventional studies.

Pubmed   Journal   ReadQx 

Urate Transporter ABCG2 Function and Asymptomatic Hyperuricemia: A Retrospective Cohort Study of CKD Progression.

Asymptomatic hyperuricemia was not associated with eGFR decline, except when in the presence of =50% ABCG2 function.

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Clin J Am Soc Nephrol

Removal of Uremic Solutes from Dialysate by Activated Carbon.

Activated carbon adsorbs many but not al uremic solutes. Introduction of activated carbon into the dialysate stream increased the clearance of those solutes that it does adsorb.

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J Am Soc Nephrol

Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic Kidney Disease.

Polycystin-2 in the ER appears to be critical for anticystogenesis and likely functions as a potassium ion channel to facilitate potassium-calcium counterion exchange for inositol trisphosphate-mediated calcium release. The results advance the understanding of ADPKD pathogenesis and provides proof of principle for pharmacotherapy by TRIC-B activators.

Pubmed   Journal   ReadQx 

Dapagliflozin Prevents Kidney Glycogen Accumulation and Improves Renal Proximal Tubule Cell Functions in a Mouse Model of Glycogen Storage Disease Type 1b.

We provide proof of concept for the efficacy of dapagliflozin in preserving kidney function in GSD1b mice. Our findings could represent the basis for repurposing this drug to treat GSD1b patients.

Pubmed   Journal   ReadQx 

Description and Outcomes of an Innovative Concurrent Hospice-Dialysis Program.

Most patients received no further dialysis treatments despite the option to continue dialysis. Our experience provides evidence to support future work testing the effectiveness of such clinical programs to improve patient and utilization outcomes.

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Hurricanes and Mortality among Patients Receiving Dialysis.

Patients requiring maintenance dialysis have a higher mortality risk in the 30 days after a hurricane.

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Optimizing the Design and Analysis of Future AKI Trials.

We also propose a road map and actionable recommendations to facilitate the adoption of the reviewed approaches. We hope that the resulting road map will help guide future clinical trial planning, maximize learning from AKI trials, and reduce the risk of missing important signals of benefit (or harm) from trial interventions.

Pubmed   Journal   ReadQx 


Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Clin J Am Soc Nephrol

Novel Approaches for the Removal of Uremic Solutes.

Pubmed   Journal   ReadQx 

J Am Soc Nephrol

Complement is Complimentary in Membranous Nephropathy.

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Nat Rev Nephrol

Immunometabolic rewiring of tubular epithelial cells in kidney disease.

TECs should therefore be considered a specialized cell type - like cells of the innate immune system - that is subject to regulation by immunometabolism. Targeting energy metabolism in TECs could represent a strategy for metabolically reprogramming the kidney and promoting kidney repair.

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies

Am J Kidney Dis

Clinical Factors and Adverse Kidney Outcomes in Children With ANCA-Associated Glomerulonephritis.

Pubmed   Journal   ReadQx 

Clin J Am Soc Nephrol

Central Venous Catheter Malfunction in Children: A Bioengineering Approach.

Pubmed   Journal   ReadQx 


Others

all remaining publications eg case reports, images of the month, etc…

Kidney Int

Novel retinal vascular phenotypes for the potential assessment of long-term risk in living kidney donors.

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